Petsoothicals Flex

Petsoothicals Flex is an unbaked soft chew which is intended for animals that currently exhibit mild to moderate stiffness and reduced mobility. Flex can also be administered to healthy animals of any age to reduce the likelihood of future joint problems.

Dogs 0 to 29lbs - 1 chew daily, 30 to 59lbs - 2 chews daily, 60 to 89lbs - 4 chews daily, 90+lbs - 6 chews daily.

Resveratrol is safe for long-term daily use, as it inhibits gene expression of the COX-2 enzyme without affecting the production of COX-1 enzymes and their gastro-protective byproduct prostaglandins. Rather than inhibiting active COX-1 and COX-2 enzymes circulating in the body, resveratrol inhibits the gene expression of COX-2 enzymes, thus reducing the level of this enzyme present in the body. Resveratrol inhibits a nuclear cofactor (NF-kappaB) that is required for gene expression of COX-2 enzymes, as well as many other pro-inflammatory compounds such as interleukins, tumor necrosis factor alpha, peroxidases, lipoxygenases and nitrous oxide synthases, but it does not affect the production of gastro-protective prostaglandins.