ITEM IS CURRENTLY ON MANUFACTURER BACKORDER. PLEASE CALL OR EMAIL FOR ESTIMATED DATE OF AVAILABILITY: email@example.com 888.837.3626. Lessens swelling and pain caused by inflammation. Prednisolone is given systemically to decrease inflammatory and immune responses.
Corticosteroid use may increase the insulin requirement because they stimulate gluconeogenesis. The immune response to vaccination may be reduced when corticosteroids are given at the same time.
Animals on immunosuppressive doses of corticosteroids should not be given modified live virus vaccines. The risk of GI ulcers may be increased if corticosteroids and other drugs prone to causing ulcers such as NSAIDs are given at the same time. Corticosteroids should not be given intravenously with fluids containing calcium.
Prednisolone is considered a shorter-acting corticosteroid. Alternate-day therapy with short-acting preparations is preferred. Animals that have received long-term therapy should be withdrawn slowly by tapering the dosage and prolonging the interval between doses.
Corticosteroids suppress immune response. Animals receiving systemic corticosteroids may be more susceptible to bacterial or viral infections. Systemic corticosteroids can mask signs of infection, such as an elevated temperature. Corticosteroids can cause or worsen gastric ulcers.
Corticosteroids should be avoided or used very carefully in young animals both because of immune suppression and the risk of GI ulcers in this population.
Corticosteroids have been implicated as a cause of laminitis in horses and ponies. Some corticosteroids are thought to be more likely to cause laminitis than others and prednisolone historically has not been considered to be in the higher-risk category. Pony breeds and horses with pituitary pars intermedia dysfunction or metabolic syndrome may be more susceptible to developing laminitis.
Corticosteroids should be avoided during pregnancy and lactation unless the benefits outweigh the risks. Large doses in early pregnancy may be teratogenic. Corticosteroids will cross into maternal milk.