Do not use in horses intended for food. Milk taken from animals during treatment and for 48 hours (4 milkings) after the last treatment with this drug must not be used for food. Cattle must not be slaughtered for food within 48 hours following the last treatment with this drug. LASIX® (furosemide) is a highly effective diuretic and if given in excessive amounts, as with any diuretic, may lead to excessive diuresis that could result in electrolyte imbalance, dehydration and reduction of plasma volume, enhancing the risk of circulatory collapse, thrombosis, and embolism. Therefore, the animal should be observed for early signs of fluid depletion with electrolyte imbalance, and corrective measures administered.
Excessive loss of potassium in patients receiving digitalis or its glycosides may precipitate digitalis toxicity. Caution should be exercised in animals administered potassium-depleting steroids.It is important to correct potassium deficiency with dietary supplementation.
Caution should be exercised in prescribing enteric-coated potassium tablets.There have been several reports in human literature, published and unpublished, concerning nonspecific small-bowel lesions consisting of stenosis, with or without ulceration, associated with the administration of enteric-coated thiazides with potassium salts. These lesions may occur with enteric-coated potassium tablets alone or when they are used with non-enteric-coated thiazides, or certain other oral diuretics. These small-bowel lesions may have caused obstruction, hemorrhage, and perforation. Surgery was frequently required and deaths have occurred.
Available information tends to imply enteric-coated potassium salts, although lesions of this type also occur spontaneously. Therefore, coated potassium containing formulations should be administered only when indicated, and should be discontinued immediately if abdominal pain, distension, nausea, vomiting, or gastro-intestinal bleeding occurs.
Human patients with known sulfonamide sensitivity may show allergic reactions to LASIX® (furosemide); however, these reactions have not been reported in animals.Sulfonamide diuretics have been reported to decrease arterial responsiveness to pressor amines and to enhance the effect of tubocurarine. Caution should be exercised in administering curare or its derivatives to patients undergoing therapy with LASIX® (furosemide) and it is advisable to discontinue LASIX® (furosemide) for one (1) day prior to any elective surgery.